Irving O. Shoichet Distinguished Lecture

CAROLYN BERTOZZI
University of California, Berkeley

ILLUMINATING GLYCANS, THE DARK MATTER OF THE CELL SURFACE

Abstract

The cell-surface glycome is dynamically regulated during development and disease progression. Interrogating these changes in real time and in live subjects is a major challenge in the fields of glycobiology and medicine. This presentation will focus on new techniques for molecular imaging of glycoconjugates and specific protein glycoforms. Applications to probing changes in glycosylation associated with embryogenesis, cancer progression and microbial infection will be discussed.

CAROLYN BERTOZZI is the T.Z. andIrmgard Chu Distinguished Professor ofChemistry and Professor of Molecular and Cell Biology at UC Berkeley, an Investigator of the Howard Hughes Medical Institute, and a Senior Faculty Scientist at the Lawrence Berkeley National Laboratory.  Her research interests span the disciplines of chemistry and biology with an emphasis on studies of cell surface glycosylation pertinent to disease states.  Her lab focuses on profiling changes in cell surface glycosylation associated with cancer, inflammation and bacterial infection, and exploiting this information for development of diagnostic and therapeutic approaches. She has been recognized with many honors and awards for her research accomplishments.  She is an elected member of the Institute of Medicine, National Academy of Sciences, and American Academy of Arts and Sciences. She has been awarded the Lemelson-MIT Prize, the Wieland Prize, and a MacArthur Foundation Fellowship, among many others.

For more info: www.chem-eng.utoronto.ca/news.htm

Websites of Interest

• University of Toronto
• Faculty of Applied Science & Engineering
• Department of Chemical Engineering & Applied Chemistry